Measurement of the Total Antioxidant Response in Acute Pancreatitis with a Novel Automated Method

The participation of oxidative stress in the pathogenesis and development of human acute (AP) and chronic 5) pancreatitis (CP) has been suggested in various reports. The oxidative stress has also been widely examined in animal models of pancreatitis most often cerulean-, taurocholateor alcohol-induced and in vitro models (pancreatic acinar cell damage) . In many organs with high oxygen metabolism, biochemical reactions that permit the continuity of life produce reactive oxygen species (ROS) that damage the cell membrane, DNA and the intracellular organelles. Oxidative stress is the resulting condition in which these harmful molecules cannot be neutralized, and it plays an important role in the aetiopathogenesis of various diseases. Oxidative stability is defined as the equilibrium between production and elimination of ROS. Any increase in the formation rate or decrease in the elimination rate of ROS can cause an imbalance leading to oxidative stress. Oxidative stress is one of the primary reasons of tissue injury or molecular damage in the cells. It has been showed that oxygen free radicals play an important role in pancreatitis with different etiologies: biliary, alcoholic, and drugand/or xenobiotic-induced pancreatitis 5, . Acta Medica Mediterranea, 2015, 31: 889